Eledon Reports Data from Ongoing Phase 1b Trial Evaluating Tegoprubart in Patients Undergoing Kidney Transplantation at World Congress of Nephrology
Results from three participants demonstrated no incidence of acute rejection at durations of 56, 154, and 232 days
Strong graft function observed in all three participants with mean eGFRs above 70 mL/min/1.73m2 at measured timepoints
Data from 16 participants in the Phase 2 IgAN study demonstrated tegoprubart to be safe and well tolerated, with no serious or severe adverse events reported
The Phase 1b open-label study is enrolling up to 12 participants undergoing kidney transplantation in
Results from the first three participants at the time of data submission to the conference demonstrated no incidence of acute rejection at 56, 167, and 232 days. The three participants had eGFRs of 54, 85, and 77 at the latest available timepoint of 49, 154, and 217 days, respectively. Regarding adverse events, one participant was discontinued from the study on day 55 after developing BK viremia, a common occurrence after kidney transplant that is related to immunosuppression and reported to occur in approximately 20% or more of kidney transplant patients. A second participant elected to discontinue the study after 33 weeks for reasons not attributed to tegoprubart or related to kidney function.
“We are highly encouraged by the results to date from our ongoing Phase 1b trial evaluating tegoprubart as a novel component of an immunosuppressive regimen in kidney transplant patients,” said
Eledon also presented safety data in a poster presentation from the Company’s Phase 2a open-label study evaluating tegoprubart for the treatment of IgAN. The available data suggests that tegoprubart is safe and well tolerated in people with IgAN, with no serious or severe adverse events reported. To date, approximately 100 human subjects have been dosed with tegoprubart across multiple disease indications.
Copies of each poster will be available on the Investor section of the Company’s website at https://ir.eledon.com/events-and-presentations/presentations.
About Eledon Pharmaceuticals and tegoprubart (formerly AT-1501)
Eledon Pharmaceuticals is a clinical stage biotechnology company using its expertise in targeting the CD40 Ligand (CD40L, also called CD154) pathway to develop potential treatments for persons requiring an organ or cell-based transplant, living with autoimmune disease, or living with ALS. The company’s lead compound in development is tegoprubart, an anti-CD40L antibody with high affinity for CD40 Ligand, a well-validated biological target with broad therapeutic potential. Eledon is headquartered in Irvine, Calif. For more information, please visit the company’s website at www.eledon.com.
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Source: Eledon Pharmaceuticals, Inc.