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                            November 6, 2020

       David-Alexandre Gros
       Chief Executive Officer
       Novus Therapeutics, Inc.
       19900 MacArthur Blvd., Suite 550
       Irvine, CA 92612

                                                        Re: Novus Therapeutics,
Inc.
                                                            Preliminary Proxy
Statement on Schedule 14A
                                                            Filed October 23,
2020
                                                            File No. 001-36620

       Dear Dr. Gros:

              We have reviewed your filing and have the following comments. In
some of our
       comments, we may ask you to provide us with information so we may better
understand your
       disclosure.

              Please respond to these comments within ten business days by
providing the requested
       information or advise us as soon as possible when you will respond. If
you do not believe our
       comments apply to your facts and circumstances, please tell us why in
your response.

                                                        After reviewing your
response to these comments, we may have additional comments.

       Preliminary Proxy Statement on Schedule 14A Filed October 23, 2020

       Reasons for the Transactions, page 13

   1.                                                   We note your disclosure
that Novus and its management team negotiated the "most
                                                        favorable equity split"
for Novus stockholders. Please revise your disclosure to quantify
                                                        the equity split by
providing the actual percentage ownership existing Novus stockholders
                                                        will own on a
fully-diluted basis following the Anelixis Acquisition.
   2.                                                   We note your disclosure
that your board of directors considered the Anelixis Acquisition
                                                        to be more favorable to
your stockholders than a potential liquidation. Please revise to
                                                        quantify the
liquidation value considered by the Board and discuss the basis for the
                                                        calculation and any
material assumptions.
 David-Alexandre Gros
FirstName LastNameDavid-Alexandre     Gros
Novus Therapeutics, Inc.
Comapany 6,
November  NameNovus
             2020      Therapeutics, Inc.
November
Page 2    6, 2020 Page 2
FirstName LastName
Proposal No. 1: Approval of Conversion Proposal, page 46

3.       We note that your Proposal No.1 Approval of Conversion Proposal is a
result of your
         acquisition of Anelixis. Please revise your proxy statement to provide
all of the
         information relating to Anelixis and the acquisition that is required
by Item 14(b)(7) of
         Schedule 14A, including the information required by Items 1005(b) and
1011(a)(1) of
         Regulation M-A. Please refer to Note A of Schedule 14A.
4.       We note your table under the subheading "Shares Issuable Upon
Conversion." Please
         revise this section to indicate the total number of shares of common
stock issued and
         reserved for issuance upon the approval of this conversion proposal.
In addition,
         please disclose the aggregate shares of common stock issuable upon
conversion in your
         narrative "Overview" sub-section directly above.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       You may contact Jason Drory at (202) 551-8342 or Joe McCann at (202)
551-6262 with
any questions.



                                                               Sincerely,

                                                               Division of
Corporation Finance
                                                               Office of Life
Sciences