101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 107 - Disclosure - Nature of the Business and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Related Party Transactions link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Summary of Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Stock-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Summary of Significant Accounting Policies - Schedule of Common Stock Equivalents, Excluded from Computation of Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense Related to Stock Options and Restricted Common Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Commitments and Contingencies (Leases) - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Commitments and Contingencies (Intellectual Property Licenses) - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Commitments and Contingencies (Commercial Development Agreement) - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Related Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink