Entity Central Index Key
Effective income tax rate reconciliation, change in warrant fair market value, amount
Income tax reconciliation permanent items.
Effective income tax rate reconciliation, section 382 limitation on net operating losses and credits.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Interactive Data Current
Entity Interactive Data Current
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
In-process research and development.
Accrued severance current.
Statement Of Financial Position [Abstract]
Statement [Table]
Statement [Table]
Class of Stock
Statement Class Of Stock [Axis]
Class of Stock
Class Of Stock [Domain]
Series X1 non-voting convertible preferred stock.
Series X1 Non-voting Convertible Preferred Stock [Member]
Series X1 Non Voting Convertible Preferred Stock [Member]
Series X convertible preferred stock.
Series X Preferred Stock [Member]
Series X Convertible Preferred Stock [Member]
Statement [Line Items]
Statement [Line Items]
ASSETS
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Operating lease asset, net
Operating Lease Right Of Use Asset
Goodwill
Goodwill
In-process research and development
In Process Research And Development
Other assets
Other Assets Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Current operating lease liability
Operating Lease Liability Current
Accrued severance
Accrued Severance Current
Accrued expenses and other liabilities
Accrued Liabilities And Other Liabilities
Total current liabilities
Liabilities Current
Deferred tax liability
Deferred Income Tax Liabilities Net
Non-current operating lease liability
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 5)
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Series X1 non-voting convertible preferred stock, $0.001 par value, 515,000 shares authorized; 108,070 and no shares issued and outstanding at December 31, 2020 and 2019, respectively
Preferred Stock Value
Common stock, $0.001 par value, 200,000,000 shares authorized at December 31, 2020 and 2019; 15,160,397 and 720,408 shares issued and outstanding at December 31, 2020 and 2019, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Warrant inducement expense.
Income Statement [Abstract]
Operating expenses
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Restructuring expense
Restructuring Charges
Goodwill impairment
Goodwill Impairment Loss
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income, net
Other Nonoperating Income Expense
Warrant inducement expense
Warrant Inducement Expense
Loss before income tax benefit
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax benefit
Income Tax Expense Benefit
Net loss and other comprehensive loss
Net Income Loss
Net loss per share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted-average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Stock issued during period value warrants exercised.
Stock issued during period shares warrants exercised.
Cancellation of common stock in exchange for preferred stock value.
Cancellation of common stock in exchange for preferred stock shares.
Cancellation of common stock in connection with reverse split value.
Cancellation of common stock in connection with reverse split shares.
Temporary equity, stock issued during period, shares, acquisitions.
Temporary equity, stock issued during period, value, acquisitions.
Temporary equity stock issued during period shares new issues.
Adjustments to additional paid in capital, fair value of options assumed in acquisition.
Adjustments to additional paid in capital, fair value of warrants assumed in acquisition.
Warrants issued during period inducement expense.
Share issuance at market value.
Share issuance at market.
Stock Issued during period value common stock and warrants.
Stock Issued during period shares common stock and warrants.
Stock issued during period cancellation of shares.
Statement Of Stockholders Equity [Abstract]
Series X one non-voting convertible preferred stock.
Series X1 Non-Voting Convertible Preferred Stock [Member]
Series X One Non Voting Convertible Preferred Stock [Member]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Beginning Balance
Temporary Equity, Beginning Balance, Shares
Temporary Equity Shares Outstanding
Temporary Equity,Beginning Balance
Temporary Equity Carrying Amount Attributable To Parent
Beginning Balance, Shares
Shares Outstanding
Issuance of common stock in connection with PIPE transaction, net of issuance costs
Stock Issued During Period Value New Issues
Issuance of preferred stock in connection with PIPE transaction, net of issuance costs, Shares
Stock Issued During Period Shares New Issues
Issuance of common stock in connection with exercise of warrants, net of issuance costs
Stock Issued During Period Value Warrants Exercised
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares
Stock Issued During Period Shares Warrants Exercised
Issuance of common stock in connection with conversion of Series X preferred stock
Stock Issued During Period Value Conversion Of Convertible Securities
Issuance of common stock in connection with conversion of Series X preferred stock, Shares
Stock Issued During Period Shares Conversion Of Convertible Securities
Issuance of common stock in connection with vesting of restricted stock units
Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures
Issuance of common stock in connection with acquisition
Stock Issued During Period Value Acquisitions
Issuance of common stock in connection with acquisition, shares
Stock Issued During Period Shares Acquisitions
Cancellation of common stock in connection with exchange for preferred stock
Cancellation Of Common Stock In Exchange For Preferred Stock Value
Cancellation of common stock in connection with exchange for preferred stock, Shares
Cancellation Of Common Stock In Exchange For Preferred Stock Shares
Cancellation of common stock in connection with reverse split
Cancellation Of Common Stock In Connection With Reverse Split Value
Cancellation of common stock in connection with reverse split, Shares
Cancellation Of Common Stock In Connection With Reverse Split Shares
Issuance of preferred stock in connection with acquisition
Temporary Equity Stock Issued During Period Value Acquisitions
Issuance of preferred stock in connection with acquisition,shares
Temporary Equity Stock Issued During Period Shares Acquisitions
Issuance of preferred stock in connection with PIPE transaction, net of issuance costs
Temporary Equity Stock Issued During Period Value New Issues
Issuance of preferred stock in connection with PIPE transaction, net of issuance costs, shares
Temporary Equity Stock Issued During Period Shares New Issues
Fair value of options assumed in acquisition
Adjustments To Additional Paid In Capital Fair Value Of Options Assumed In Acquisition
Fair value of warrants assumed in acquisition
Adjustments To Additional Paid In Capital Fair Value Of Warrants Assumed In Acquisition
Warrant inducement expense
Warrants Issued During Period Inducement Expense
Issuance of common stock at-the-market, net of issuance costs
Share Issuance At Market Value
Issuance of common stock at-the-market, net of issuance costs, Shares
Share Issuance At Market
Issuance of common stock and warrants in registered direct offering, net of issuance costs
Stock Issued During Period Value Common Stock And Warrants
Issuance of common stock and warrants in registered direct offering, net of issuance costs, shares
Stock Issued During Period Shares Common Stock And Warrants
Issuance of common stock in connection with vesting of restricted stock units
Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures
Cancellation of common stock, Shares
Stock Issued During Period Cancellation Of Shares
Stock-based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Net loss and other comprehensive loss
Ending Balance
Temporary Equity, Ending Balance, Shares
Temporary Equity,Ending Balance
Ending Balance, Shares
Amortization of operating lease asset.
Deferred tax liability.
Increase decrease in operating lease liability.
Cash paid for cancellation of common stock in connection with reverse split.
Conversion of Series X1 preferred stock into common stock.
Issuance of common stock in acquisition.
Issuance of non-voting convertible preferred stock in acquisition.
Fair value of options assumed in acquisition.
Fair value of warrants assumed in acquisition.
Accrued offering costs.
Statement Of Cash Flows [Abstract]
Operating activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation and amortization
Depreciation And Amortization
Amortization of operating lease asset
Amortization Of Operating Lease Asset
Warrant inducement expense
Stock-based compensation
Allocated Share Based Compensation Expense
Deferred income taxes
Deferred Tax Liability
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable and accrued expenses
Increase Decrease In Accounts Payable And Accrued Liabilities
Operating lease liability
Increase Decrease In Operating Lease Liability
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Investing activities
Net Cash Provided By Used In Investing Activities [Abstract]
Cash and cash equivalents received from acquisition
Cash Acquired From Acquisition
Net cash provided by investing activities
Net Cash Provided By Used In Investing Activities
Financing activities
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from issuance of common stock, net
Proceeds From Issuance Of Common Stock
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net
Proceeds From Issuance Of Preferred Stock And Preference Stock
Proceeds from exercise of warrants, net
Proceeds From Warrant Exercises
Cash paid for cancellation of common stock in connection with reverse split
Cash Paid For Cancellation Of Common Stock In Connection With Reverse Split
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net change in cash and cash equivalents
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash and cash equivalents at beginning of year
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash and cash equivalents at end of year
Supplemental disclosure of non-cash investing and financing activities
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Conversion of Series X1 preferred stock into common stock
Conversion Of Series X1 Preferred Stock Into Common Stock
Issuance of common stock in acquisition
Issuance Of Common Stock In Acquisition
Issuance of non-voting convertible preferred stock in acquisition
Issuance Of Non Voting Convertible Preferred Stock In Acquisition
Fair value of options assumed in acquisition
Fair Value Of Options Assumed In Acquisition
Fair value of warrants assumed in acquisition
Fair Value Of Warrants Assumed In Acquisition
Accrued offering costs
Accrued Offering Costs
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Accounting Policies [Abstract]
Description of Business
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Prepaid expenses, other assets, accrued expenses and other liabilities.
Prepaid expenses, other assets, accrued expenses and other liabilities.
Prepaid Expenses Other Assets Accrued Expenses And Other Liabilities [Abstract]
Prepaid Expenses, Other Assets, Accrued Expenses and Other Liabilities
Prepaid Expenses Other Assets Accrued Expenses And Other Liabilities [Text Block]
Goodwill And Intangible Assets Disclosure [Abstract]
Goodwill
Goodwill Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Equity [Abstract]
Stockholders' Equity
Stockholders Equity Note Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Restructuring And Related Activities [Abstract]
Restructuring Expense
Restructuring And Related Activities Disclosure [Text Block]
Business Combinations [Abstract]
Business Acquisition
Business Combination Disclosure [Text Block]
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Basis of presentation and principles of consolidation.
Basis of Presentation and Principles of Consolidation
Basis Of Presentation And Principles Of Consolidation Policy [Text Block]
Liquidity and financial condition.
Liquidity and Financial Condition
Liquidity And Financial Condition Policy [Text Block]
Use of Estimates
Use Of Estimates
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Concentration of credit risk and other risks and uncertainties.
Concentration of Credit Risk and Other Risks and Uncertainties
Concentration Of Credit Risk And Other Risks And Uncertainties Policy [Text Block]
Business Combinations
Business Combinations Policy
Reportable Segments
Segment Reporting Policy Policy [Text Block]
Goodwill
Goodwill And Intangible Assets Goodwill Policy
Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
In-Process Research and Development
In Process Research And Development Policy
Research and Development Expenses
Research And Development Expense Policy
Net Loss Per Share
Earnings Per Share Policy [Text Block]
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Income Taxes
Income Tax Policy [Text Block]
Recently Issued or Adopted Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Schedule of Common Share Equivalents Included from Computation of Net Loss Per Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Prepaid Expenses and Other Current Assets
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Text Block]
Schedule of accrued expenses and other liabilities.
Schedule of Accrued Expenses and Other Liabilities
Schedule Of Accrued Expenses And Other Liabilities Table [Text Block]
Schedule of Changes in the Carrying Amount of Goodwill
Schedule Of Goodwill [Text Block]
Components of Lease Expense
Lease Cost Table [Text Block]
Other information related to leases.
Schedule of Other Information Related to Leases
Other Information Related To Leases Table [Text Block]
Schedule of Future Payments Under Noncancelable Operating Leases
Lessee Operating Lease Liability Maturity Table [Text Block]
Summary of Loss Before Income Taxes
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Summary of Provision (Benefit) for Income Taxes
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Reconciliation of U.S. Federal Statutory Income Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Significant Components Deferred Tax Assets and Liabilities
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits
Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block]
Schedule of warrant activity.
Class Of Warrant Or Right [Table]
Class Of Warrant Or Right [Table]
Business Acquisition
Business Acquisition [Axis]
Business Acquisition, Acquiree
Business Acquisition Acquiree [Domain]
Anelixis Therapeutics, Incorporation.
Anelixis [Member]
Anelixis Therapeutics Incorporation [Member]
Class Of Warrant Or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Schedule of Warrant Activity
Schedule Of Warrant Activity Table [Text Block]
Summary of Stock Option Activity
Schedule Of Stock Options Roll Forward Table [Text Block]
Summary of PRSU Activity
Share Based Compensation Performance Shares Award Unvested Activity Table [Text Block]
Schedule of Stock-Based Compensation Expense Related to Stock-Based Awards
Schedule Of Compensation Cost For Share Based Payment Arrangements Allocation Of Share Based Compensation Costs By Plan Table [Text Block]
Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine the Fair Value of Stock Options Granted
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Total Liability For Restructuring Expenses and Their Utilization
Schedule Of Restructuring Reserve By Type Of Cost [Text Block]
Summary of Fair Value of Purchase Price Consideration
Schedule Of Business Acquisitions By Acquisition [Text Block]
Summary of Preliminary Estimate of Fair Value of Assets Acquired and Liabilities Assumed
Schedule Of Recognized Identified Assets Acquired And Liabilities Assumed Table [Text Block]
Schedule of Unaudited Pro Forma Combined Financial Information
Business Acquisition Pro Forma Information [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Description of business.
Description of business.
Description Of Business [Table]
Description Of Business [Table]
Description Of Business [Line Items]
Description Of Business [Line Items]
Date of acquisition
Business Acquisition Effective Date Of Acquisition1
Summary of significant accounting policies.
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Legal Entity
Legal Entity [Axis]
Entity
Entity [Domain]
Otic Pharma, Ltd.
Otic Pharma [Member]
Otic Pharma Ltd [Member]
Otic Pharma, Inc.
Otic Pharma, Inc. [Member]
Otic Pharma Inc [Member]
Common Stock [Member]
Series X one convertible preferred stock.
Series X1 Preferred Stock [Member]
Series X One Convertible Preferred Stock [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
September two thousand twenty stock purchase agreement.
Stock Purchase Agreement [Member]
September Two Thousand Twenty Stock Purchase Agreement [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Maximum [Member]
Maximum [Member]
Minimum [Member]
Minimum [Member]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Measurements, Recurring [Member]
Fair Value Measurements Recurring [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Options [Member]
Employee Stock Option [Member]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Board of Directors [Member]
Board Of Directors Chairman [Member]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand fourteen stock incentive plan.
2014 Stock Incentive Plan [Member]
Two Thousand Fourteen Stock Incentive Plan [Member]
Two thousand fourteen employee stock purchase plan.
2014 Employee Stock Purchase Plan [Member]
Two Thousand Fourteen Employee Stock Purchase Plan [Member]
Two thousand twenty long term incentive plan.
2020 Plan [Member]
Two Thousand Twenty Long Term Incentive Plan [Member]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Ownership percentage
Equity Method Investment Ownership Percentage
Working capital.
Cash used in operating activities
Cash and cash equivalents
Working capital
Working Capital
Preferred stock shares issuable under agreement.
Preferred stock value of share issuable.
Business combination additional commitments in equity financing.
Preferred stock shares agreed to sell
Preferred Stock Shares Issuable Under Agreement
Preferred stock shares aggregate purchase price
Preferred Stock Value Of Share Issuable
Business combination additional commitments in equity financing
Business Combination Additional Commitments In Equity Financing
Shares of common stock issued upon conversion of each share of preferred stock
Convertible Preferred Stock Shares Issued Upon Conversion
Common stock, number of shares sold
Closing bid price per NASDAQ listing notification letter.
Consecutive business days for closing bid price of common stock.
Closing bid price per NASDAQ listing notification letter
Closing Bid Price Per N A S D A Q Listing Notification Letter
Consecutive business days for closing bid price of common stock
Consecutive Business Days For Closing Bid Price Of Common Stock
Number of consecutive trading days required to regain compliance.
Reverse stock split, description
Stockholders Equity Reverse Stock Split
Number of consecutive trading days required to regain compliance
Number Of Consecutive Trading Days Required To Regain Compliance
Stock price per share
Sale Of Stock Price Per Share
Cash cash equivalents and restricted cash maturity period.
Cash, cash equivalents and restricted cash, maturity period
Cash Cash Equivalents And Restricted Cash Maturity Period
Cash equivalents
Cash Equivalents At Carrying Value
Financial assets transfers level 1 to 2
Fair Value Assets Level1 To Level2 Transfers Amount
Financial assets transfers level 2 to 1
Fair Value Assets Level2 To Level1 Transfers Amount
Financial liabilities transfers level 1 to 2
Fair Value Liabilities Level1 To Level2 Transfers Amount
Financial liabilities transfers level 2 to 1
Fair Value Liabilities Level2 To Level1 Transfers Amount
Assets measured at fair value
Assets Fair Value Disclosure
Liabilities measured at fair value
Liabilities Fair Value Disclosure
Number of operating business segments
Number Of Operating Segments
Number of reporting units
Number Of Reporting Units
Impairment charge
Impairments of long-lived assets
Impairment Of Long Lived Assets Held For Use
Earnings Per Share [Abstract]
Antidilutive securities excluded from computation of earnings per share, amount
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Expected life assumption using simplified method, description
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Term Simplified Method
Vesting period of stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Expected life assumption using simplified method
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Increase in number of shares of common stock authorized for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Common stock, number of shares reserved for issuance
Common Stock Capital Shares Reserved For Future Issuance
Percentage of issued and outstanding shares of common stock
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Maximum
Equity compensation period
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Tax benefit
Tax Cuts And Jobs Act Of2017 Change In Tax Rate Income Tax Expense Benefit
Income tax examination likelihood of favorable settlement.
Income tax examination, likelihood of settlement, description
Income Tax Examination Likelihood Of Unfavorable Settlement
Income tax examination, likelihood of settlement, percentage
Income Tax Examination Likelihood Of Favorable Settlement
Prepaid clinical expense.
Prepaid Expense And Other Assets Current [Abstract]
Prepaid insurance
Prepaid Insurance
Prepaid clinical
Prepaid Clinical Expense
Prepaid other
Other Prepaid Expense Current
Insurance receivable
Insurance Settlements Receivable Current
Other current assets
Other Assets Current
Total prepaid expenses and other current assets
Accrued clinical current.
Accrued financing costs.
Accrued Liabilities And Other Liabilities [Abstract]
Accrued compensation and related expenses
Workers Compensation Liability Current
Accrued clinical
Accrued Clinical Current
Accrued professional services
Accrued Professional Fees Current
Accrued vacation
Accrued Vacation Current
Accrued costs associated with PIPE financing
Accrued Financing Costs
Accrued other
Other Accrued Liabilities Current
Total accrued expenses and other liabilities
Schedule Of Goodwill [Table]
Schedule Of Goodwill [Table]
Goodwill [Line Items]
Goodwill [Line Items]
Gross Carrying Amount, Beginning balance
Goodwill Gross
Impairments
Acquisition of Anelixis
Goodwill Acquired During Period
Gross Carrying Amount, Ending balance
Other Commitments [Table]
Other Commitments [Table]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Irvine, California
CALIFORNIA
Burlington, Massachusetts
MASSACHUSETTS
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
ALS therapy development foundation, Inc. license agreement.
ALS Therapy Development Foundation, Inc. License Agreement [Member]
A L S Therapy Development Foundation Inc License Agreement [Member]
Category of Item Purchased
Long Term Purchase Commitment By Category Of Item Purchased [Axis]
Long-term Purchase Commitment, Category of Item Purchased
Long Term Purchase Commitment Category Of Item Purchased [Domain]
Five hundred million aggregate net sales.
Achievement of 500 Million Aggregate Sales [Member]
Five Hundred Million Aggregate Net Sales [Member]
One billion aggregate net sales.
Achievement of 1 Billion Aggregate Sales [Member]
One Billion Aggregate Net Sales [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Office of chief scientist of Israeli ministry of economy and industry.
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]
Office Of Chief Scientist Of Israeli Ministry Of Economy And Industry [Member]
Licensors.
Scientific Development and Research, Inc. and Otodyne, Inc. [Member]
Licensors [Member]
Other Commitments
Other Commitments [Axis]
Other Commitments
Other Commitments [Domain]
License agreement.
License Agreement [Member]
License Agreement [Member]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development Expenses [Member]
Research And Development Expense [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Rental expense
Lease And Rental Expense
Area of office space.
Number of office spaces operating lease.
Area of office space
Area Of Office Space
Lease expiration date
Lease Expiration Date1
Number of office spaces operating lease
Number Of Office Spaces Operating Lease
Lessee operating lease remaining term of contract.
Remaining term of office lease
Lessee Operating Lease Remaining Term Of Contract
Debt outstanding
Debt Longterm And Shortterm Combined Amount
Operating lease cost
Operating Lease Cost
Cash paid for amounts included in measurement of lease liabilities.
Operating lease asset obtained in exchange for lease liability.
Remaining lease term.
Discount rate.
Supplemental Cash Flows Information
Supplemental Cash Flow Information [Abstract]
Cash paid for amounts included in the measurement of lease liability:
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Operating cash flows from operating lease
Operating Lease Payments
Operating lease asset obtained in exchange for lease liability:
Operating Lease Asset Obtained In Exchange For Lease Liability [Abstract]
Operating lease
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Remaining lease term
Remaining Lease Term [Abstract]
Operating lease
Operating Lease Weighted Average Remaining Lease Term1
Discount rate
Discount Rate [Abstract]
Operating lease
Operating Lease Weighted Average Discount Rate Percent
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
Total minimum lease payments
Lessee Operating Lease Liability Payments Due
Less imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Present value of lease liabilities
Operating Lease Liability
Less current portion
Lessee short term operating lease liability payments due next twelve months.
Future payment under short term 2021
Lessee Short Term Operating Lease Liability Payments Due Next Twelve Months
Fee due for milestones achieved.
Number of milestones achieved.
Fee due for milestones achieved
Fee Due For Milestones Achieved
Common stock issued in lieu of making a cash payment
Stock Issued1
Number of Milestones Achieved
Number Of Milestones Achieved
Remaining milestone payments for first licensed product.
Regulatory milestone payments obligation.
Remaining milestone payments for first licensed product
Remaining Milestone Payments For First Licensed Product
Development and regulatory milestone payments
Regulatory Milestone Payments Obligation
Annual license maintenance fee.
Annual License Maintenance Fee
Annual License Maintenance Fee
Aggregate net sales achievement.
Reaching of aggregate net sales
Aggregate Net Sales Achievement
Amount of one-time milestone payment
Royalty Guarantees Commitments Amount
Grants received.
Grants received
Grants Received
License fees paid
Cost Of Goods And Services Sold
Sales milestones payments obligation.
Sales required to trigger milestone.
Royalty payments period.
Milestone payment made.
Sales based milestone payment
Sales Milestones Payments Obligation
Sales required to achieve milestone payment
Sales Required To Trigger Milestone
Royalty payment period
Royalty Payments Period
Milestone payment
Milestone Payment Made
Indemnification obligations amount
Guarantee Obligations Current Carrying Value
Contingent liability.
Contingent liabilities
Contingent Liability
Losses before income taxes:
Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments [Abstract]
U.S.
Income Loss From Continuing Operations Before Income Taxes Domestic
Non-U.S.
Income Loss From Continuing Operations Before Income Taxes Foreign
Total
Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments
Current:
Current Income Tax Expense Benefit Continuing Operations [Abstract]
Federal
Current Federal Tax Expense Benefit
State
Current State And Local Tax Expense Benefit
Foreign
Current Foreign Tax Expense Benefit
Current income tax expense (benefit)
Current Income Tax Expense Benefit
Deferred:
Deferred Income Tax Expense Benefit Continuing Operations [Abstract]
Federal
Deferred Federal Income Tax Expense Benefit
State
Deferred State And Local Income Tax Expense Benefit
Foreign
Deferred Foreign Income Tax Expense Benefit
Deferred income tax expense (benefit)
Deferred Income Tax Expense Benefit
Provision (benefit) for income taxes
Effective federal and state income tax rate.
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Table]
Income Tax Authority, Name
Income Tax Authority Name [Axis]
Income Tax Authority, Name
Income Tax Authority Name [Domain]
Israeli Tax Authority [Member]
Israel Tax Authority [Member]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Foreign Country [Member]
Foreign Country [Member]
Domestic Tax Authority [Member]
Domestic Country [Member]
State and Local Jurisdiction [Member]
State And Local Jurisdiction [Member]
California [Member]
California Franchise Tax Board [Member]
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Line Items]
Income tax rate
Effective Income Tax Rate Continuing Operations
Federal Income tax rate
Effective Federal And State Income Tax Rate
Statutory Federal income tax rate
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
Tax credits
Income Tax Reconciliation Tax Credits
Change in warrant fair market value
Effective Income Tax Rate Reconciliation Change In Warrant Fair Market Value Amount
Stock-based compensation
Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost
Goodwill impairment
Income Tax Reconciliation Nondeductible Expense Impairment Losses
Permanent items
Income Tax Reconciliation Permanent Items
Section 382 limitation on net operating losses and credits
Effective Income Tax Rate Reconciliation Section Three Hundred And Eighty Two Limitation On Net Operating Losses And Credits
Other
Income Tax Reconciliation Other Adjustments
Change in valuation allowance
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
Deferred tax assets depreciation and amortization.
Deferred tax assets lease liability.
Deferred tax assets right-of-use asset.
Deferred tax liabilities, in-process research and development.
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and development tax credits
Deferred Tax Assets Tax Credit Carryforwards Research
Accruals and reserves
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
Stock compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Depreciation and amortization
Deferred Tax Assets Depreciation And Amortization
Lease liability
Deferred Tax Assets Lease Liability
Total deferred tax assets
Deferred Tax Assets Gross
Right-of-use asset
Deferred Tax Assets Right Of Use Asset
Acquired IPR&D
Deferred Tax Liabilities In Process Research And Development
Total deferred tax liabilities
Deferred Income Tax Liabilities
Less: valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax liabilities
Deferred Tax Liabilities
Gross unrecognized tax benefits at the beginning of the year
Unrecognized Tax Benefits
Additions from tax positions taken in the current year
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
Additions from tax positions taken in prior years
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
Reductions from tax positions taken in prior years
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
Tax settlements
Unrecognized Tax Benefits Increases Resulting From Settlements With Taxing Authorities
Gross unrecognized tax benefits at the end of the year
Net valuation allowance decreased
Valuation Allowance Deferred Tax Asset Change In Amount
Net operating loss carryforwards expiration period.
Federal net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards Domestic
State net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards State And Local
Foreign operating losses carryforwards
Deferred Tax Assets Operating Loss Carryforwards Foreign
Net operating loss carryforward expiration period
Net Operating Loss Carryforwards Expiration Period
Federal net operating loss carryforwards, not to expiration
Deferred Tax Assets Operating Loss Carryforwards Not Subject To Expiration
Tax credit carryforward expiration period.
Tax credit carryforward expiration description.
Research and development tax credit carryforwards for federal and state
Research and development tax credit carryforwards expiration period
Tax Credit Carryforward Expiration Period
Research and development tax credit carryforwards expiration description
Tax Credit Carryforward Expiration Description
Percentage of cumulative change in ownership.
Period for which cumulative change in ownership annual use net operating loss and research and development credit carryforwards.
Percentage of cumulative change in ownership
Percentage Of Cumulative Change In Ownership
Period for which cumulative change in ownership annual use net operating loss and research and development credit carryforwards
Period For Which Cumulative Change In Ownership Annual Use Net Operating Loss And Research And Development Credit Carryforwards
Section 382 limitation on net operating losses and R&D credit carryforwards
Accrued interest and penalties associated with uncertain tax positions
Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued
Interest or penalties recorded during the year
Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
Equity distribution agreement maximum value of common shares issuable.
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Piper Jaffray and Co.
Piper Jaffray & Co. [Member]
Piper Jaffray And Co [Member]
Equity distribution agreement.
Equity Distribution Agreement [Member]
Equity Distribution Agreement [Member]
Securities purchase agreement.
Securities Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Private Placement [Member]
Private Placement [Member]
Placement agent.
Placement Agent [Member]
Placement Agent [Member]
Series A warrants.
Series A Warrants [Member]
Series A Warrants [Member]
Series B warrants.
Series B Warrants [Member]
Series B Warrants [Member]
Maximum [Member]
Two thousand nineteen equity offering.
2019 Equity Offering [Member]
Two Thousand Nineteen Equity Offering [Member]
Warrant exercise agreements.
Warrant Exercise Agreements [Member]
Warrant Exercise Agreements [Member]
Class of Warrant or Right
Class Of Warrant Or Right [Axis]
Class of Warrant or Right
Class Of Warrant Or Right [Domain]
Series A warrants and series B warrants.
Warrants [Member]
Series A Warrants And Series B Warrants [Member]
Series X One Preferred Stock.
Series X1 Preferred Stock [Member]
Series X One Preferred Stock [Member]
Warrant [Member]
Warrant [Member]
Common Stock Options [Member]
Exchange agreement.
Exchange Agreement [Member]
Exchange Agreement [Member]
Biotechnology Value Fund L P Biotechnology Value Fund II L P and Biotechnology Value Trading Fund OS L.P.
Exchanging Stockholders [Member]
Biotechnology Value Fund L P Biotechnology Value Fund I I L P And Biotechnology Value Trading Fund O S L P [Member]
Series X exchange agreement.
Series X Exchange Agreement [Member]
Series X Exchange Agreement [Member]
Biotechnology Value Fund LP, Biotechnology Value Fund II LP, Biotechnology Value Trading Fund OS LP, MSI BVF SPV LLC and Cormorant Global Healthcare Master Fund LP.
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member]
Biotechnology Value Fund L P Biotechnology Value Fund I I L P Biotechnology Value Trading Fund O S L P M S I B V F S P V L L C And Cormorant Global Healthcare Master Fund L P [Member]
Warrant exchange agreement and series x exchange agreement.
Warrant Exchange Agreement and Exchange Agreements [Member]
Warrant Exchange Agreement And Series X Exchange Agreement Member [Member]
Biotechnology Value Fund LP, Biotechnology Value Fund II LP, Biotechnology Value Trading Fund OS LP, MSI BVF SPV LLC.
BVF Exchanging Stockholders
Biotechnology Value Fund L P Biotechnology Value Fund I I L P Biotechnology Value Trading Fund O S L P M S I B V F S P V L L C [Member]
Class Of Stock [Line Items]
Class Of Stock [Line Items]
Equity distribution agreement maximum value of common shares issuable
Equity Distribution Agreement Maximum Value Of Common Shares Issuable
Common stock number of shares issued
Proceeds from issuance of common stock
Common stock shares issuable under direct offering.
Common stock value of shares issuable.
Warrants exercisable term.
Warrants offering price maturity date.
Percentage class of warrant or right number of securities called by warrants or rights.
Common stock shares agreed to sell
Common Stock Shares Issuable Under Direct Offering
Common stock shares agreed to sell, gross proceeds value
Common Stock Value Of Shares Issuable
Warrants to issue shares of common stock
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Warrant exercise price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrants exercisable term
Warrants Exercisable Term
Percentage of warrants to issue shares of common stock
Percentage Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Warrants offering price maturity date
Warrants Offering Price Maturity Date
Class of warrant or right reduced exercise price of warrants.
Class of warrant or right additional exercise price of warrants.
Warrant reduced exercise price per share
Class Of Warrant Or Right Reduced Exercise Price Of Warrants
Warrant additional exercise price per share
Class Of Warrant Or Right Additional Exercise Price Of Warrants
Class of warrant or right number of warrants exercised.
Number of shares exercised
Class Of Warrant Or Right Number Of Warrants Or Rights Exercised
Warrants available for exercise
Class Of Warrant Or Right Outstanding
Class of warrant or right number of warrants or rights issued.
Class of warrant or right number of warrants or rights cancelled or expired.
Class of warrant or right number of warrants or rights assumed and replaced.
Registered Direct Warrants, Placement Agent [Member]
Private Placement Warrants [Member]
Private placement warrants, placement agent.
Private Placement Warrants, Placement Agent [Member]
Private Placement Warrants Placement Agent [Member]
Registered Direct Warrants, Series A [Member]
Registered Direct Warrants, Series B [Member]
Warrants assumed and replaced in acquisition.
Warrants Assumed and Replaced in Acquisition [Member]
Warrants Assumed And Replaced In Acquisition [Member]
Beginning Balance
Assumed and replaced
Class Of Warrant Or Right Number Of Warrants Or Rights Assumed And Replaced
Issued
Class Of Warrant Or Right Number Of Warrants Or Rights Issued
Exercised
Cancelled/Expired
Class Of Warrant Or Right Number Of Warrants Or Rights Cancelled Or Expired
Ending Balance
Share based compensation arrangement by share based payment award options assumed and replaced.
Issuance of common stock
Business Acquisition Equity Interests Issued Or Issuable Number Of Shares Issued
Estimated fair value, assumed and replaced
Share Based Compensation Arrangement By Share Based Payment Award Options Assumed And Replaced
Estimated fair value, assumed and replaced value
Business Combination Consideration Transferred Other1
Reimbursement of expenses.
Conversion of stock, shares converted
Conversion Of Stock Shares Converted1
Conversion of stock, shares issued
Conversion Of Stock Shares Issued1
Reimbursement of expenses
Reimbursement Of Expenses
Number of designated preferred stock shares.
Conversion of stock blocker provision percentage.
Number of designated preferred stock shares
Number Of Designated Preferred Stock Shares
Conversion of stock blocker provision percentage
Conversion Of Stock Blocker Provision Percentage
Number of embedded features within preferred stock.
Number of embedded features within preferred stock
Number Of Embedded Features Within Preferred Stock
Number of common stock, shares issued upon conversion.
Number of common stock, shares issued upon conversion
Number Of Common Stock Shares Issued Upon Conversion
Preferred shares outstanding
Preferred stock value of shares issuable.
Issuance of preferred stock
Preferred stock shares aggregate purchase price
Preferred Stock Value Of Shares Issuable
Number of stock compensation plans.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Two thousand twenty stock incentive plan.
2020 Stock Incentive Plan [Member]
Two Thousand Twenty Stock Incentive Plan [Member]
Two thousand seven stock incentive plan.
2007 Stock Incentive Plan [Member]
Two Thousand Seven Stock Incentive Plan [Member]
PRSUs [Member]
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of stock compensation plans
Number Of Stock Compensation Plans
Common stock, shares authorized for issuance
Common stock reverse stock split ratio
Stockholders Equity Note Stock Split Conversion Ratio1
Common stock reverse stock split description
Number of options outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Options granted, expiration period
Stock awards available for grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Stock awards available for grant
Share based compensation arrangement by share based payment award, options, in connection with acquisition.
Shares Issuable Under Options
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Outstanding, beginning balance
Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Options assumed in connection with acquisition
Share Based Compensation Arrangement By Share Based Payment Award Options In Connection With Acquisition
Exercised
Stock Issued During Period Shares Stock Options Exercised
Forfeited / Canceled
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
Outstanding, ending balance
Options vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Options exercisable as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Share based compensation arrangement by share based payment award, options, in connection with acquisition, weighted average exercise price.
Weighted Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Outstanding, beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Options assumed in connection with acquisition
Share Based Compensation Arrangement By Share Based Payment Award Options In Connection With Acquisition Weighted Average Exercise Price
Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Forfeited / Canceled
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price
Outstanding, ending balance
Options vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Options exercisable as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Options Weighted Average Remaining Contractual Term [Abstract]
Weighted Average Remaining Contractual Term (In years)
Share Based Compensation Arrangement By Share Based Payment Award Options Weighted Average Remaining Contractual Term [Abstract]
Outstanding, balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Options vested and expected to vest as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Options exercisable as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Aggregate intrinsic value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Options vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Options exercisable as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Share based compensation arrangement by share based payment award, equity instruments other than options, forfeited and canceled in period.
Share based compensation arrangement by share based payment award, equity instruments other than options, vested and expected to vest, outstanding, number.
Shares Issuable Under PRSUs
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward
Outstanding, beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
PRSUs Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Forfeited / Canceled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited And Canceled In Period
Outstanding, ending balance
PRSUs vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested And Expected To Vest Outstanding Number
Share based compensation arrangement by share based payment award, equity instruments other than options, grants in period, weighted average exercise price.
Share based compensation arrangement by share based payment award, equity instruments other than options, vested in period, weighted average exercise price.
Share based compensation arrangement by share based payment award, equity instruments other than options, forfeited and canceled in period, weighted average exercise price.
Share based compensation arrangement by share based payment award equity instruments other than options, nonvested, weighted average exercise price.
Share based compensation arrangement by share based payment award, equity instruments other than options, nonvested, weighted average exercise price.
Share based compensation arrangement by share based payment award, equity instruments other than options, vested and expected to vest, outstanding, weighted average exercise price.
Weighted Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Exercise Price [Abstract]
Outstanding, beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Exercise Price
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Exercise Price
PRSUs Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Exercise Price
Forfeited / Canceled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited And Canceled In Period Weighted Average Exercise Price
Outstanding, ending balance
PRSUs vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Share based compensation arrangement by share based payment award equity instruments other than options, weighted average remaining contractual terms.
Weighted Average Remaining Contractual Term (In years)
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Weighted Average Remaining Contractual Terms [Abstract]
Outstanding as of January 1, 2019
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Outstanding Weighted Average Remaining Contractual Terms
Share based compensation arrangement by share based payment award, equity instruments other than options, vested and expected to vest, outstanding aggregate intrinsic value.
Aggregate Intrinsic Value
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value [Abstract]
Aggregate intrinsic value, Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Nonvested
PRSUs vested and expected to vest as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Range of exercise prices
Aggregate intrinsic value of options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Unrecognized stock-based compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized
Unrecognized stock-based compensation expense, recognized over estimated weighted average period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Share Based Arrangements To Obtain Goods And Services [Abstract]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Research and Development [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense
Number of shares vested
Value of shares vested
Expected stock price volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Expected stock price volatility, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
Expected stock price volatility, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Risk-free interest rate, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
Risk-free interest rate, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
Expected life of option (in years)
Estimated dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Expenses related to workforce reduction
Accrued restructuring charges at beginning of period
Restructuring Reserve
Paid
Payments For Restructuring
Accrued restructuring charges at end of period
Schedule Of Business Acquisitions By Acquisition [Table]
Schedule Of Business Acquisitions By Acquisition [Table]
Stock Purchase Agreement [Member]
Series X1 Preferred Stock [Member]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
In-Process Research and Development [Member]
In Process Research And Development [Member]
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Business acquisition, date of acquisition
Shares Issued to stockholders of acquiree
Common stock, par value
Shares of common stock issued upon conversion of each share of preferred stock
Preferred stock shares aggregate purchase price
Shares of common stock sold
Proceeds from issuance of common stock
Preferred Stock [Member]
Preferred Stock [Member]
Fair value of purchase consideration:
Business Combination Consideration Transferred [Abstract]
Awards assumed
Business Combination Consideration Transferred Equity Interests Issued And Issuable
Awards assumed
Total purchase consideration
Business Combination Consideration Transferred1
Business acquisition, shares issued
Business acquisition, closing price per share
Business Acquisition Share Price
Business combination recognized identifiable assets acquired and liabilities assumed accrued expenses and other liabilities.
Cash and cash equivalents
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Cash And Equivalents
Prepaid expenses and other current assets
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Current Assets Prepaid Expense And Other Assets
Other non-current assets
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Other Noncurrent Assets
Accounts payable
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Current Liabilities Accounts Payable
Accrued expenses and other liabilities
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Accrued Expenses And Other Liabilities
Deferred tax liability
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Deferred Tax Liabilities
Net identifiable assets acquired
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Net
Identifiable intangible assets
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Intangibles
Net assets acquired
Business Combination Recognized Identifiable Assets Acquired Goodwill And Liabilities Assumed Net
Business acquisition costs
Business Combination Acquisition Related Costs
Estimated fair value related to clinical development program
Gain from forgiveness of debt excluded from pro forma combined financial information
Gains Losses On Extinguishment Of Debt
Other expenses excluded from pro forma combined financial information
Other General Expense
Business acquisitions pro forma research and development expense.
Business acquisition pro forma general and administrative expense.
Business acquisitions pro forma restructuring expense.
Business acquisitions pro forma goodwill impairment.
Business acquisition, pro forma operating expenses.
Business acquisition, pro forma operating income (loss).
Business acquisition, pro forma other nonoperating income (expense).
Business acquisition pro forma warrant inducement expense.
Business acquisition pro forma income loss before provision for income taxes.
Business acquisition pro forma income tax expense benefit.
Business acquisition, pro forma net income (loss) and other comprehensive income (loss).
Business acquisition, pro forma earnings per share, basic and diluted.
Business acquisition pro forma weighted average number of shares outstanding, basic and diluted.
Business acquisition, pro forma operating expenses.
Revenue
Business Acquisitions Pro Forma Revenue
Operating expenses
Business Acquisition Pro Forma Operating Expenses [Abstract]
Research and development
Business Acquisitions Pro Forma Research And Development Expense
General and administrative
Business Acquisition Pro Forma General And Administrative Expense
Restructuring expense
Business Acquisitions Pro Forma Restructuring Expense
Goodwill impairment
Business Acquisitions Pro Forma Goodwill Impairment
Total operating expenses
Business Acquisition Pro Forma Operating Expenses
Loss from operations
Business Acquisition Pro Forma Operating Income Loss
Other income (expense), net
Business Acquisition Pro Forma Other Nonoperating Income Expense
Warrant inducement expense
Business Acquisition Pro Forma Warrant Inducement Expense
Loss before provision for income taxes
Business Acquisition Pro Forma Income Loss Before Provision For Income Taxes
Income tax benefit
Business Acquisition Pro Forma Income Tax Expense Benefit
Net loss and other comprehensive loss
Business Acquisition Pro Forma Net Income Loss And Other Comprehensive Income Loss
Net loss per share, basic and diluted
Business Acquisition Pro Forma Earnings Per Share Basic And Diluted
Weighted-average shares outstanding, basic and diluted
Business Acquisition Pro Forma Weighted Average Number Of Shares Outstanding Basic And Diluted
Net loss and other comprehensive loss
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Open market sale agreement.
Open Market Sale Agreement [Member]
Open Market Sale Agreement [Member]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Jefferies limited liability company.
Jefferies LLC [Member]
Jefferies Limited Liability Company [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Percentage of gross proceeds of shares of common stock.
Percentage of gross proceeds of shares of common stock
Percentage Of Gross Proceeds Of Shares Of Common Stock