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995695 - Disclosure - Restatement of Previously Issued Consolidated Financial Statements (Tables)
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995765 - Disclosure - Fair Value Measurements - Schedule of Aggregate Fair Value of Warrant Liability (Details)
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995895 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense Recognized (Detail)
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995955 - Disclosure - Restatement of Previously Issued Consolidated Financial Statements - Summary of Impact of Correction of Misstatements - Corrected Condensed Consolidated Statements of Operations and Comprehensive Loss (Details)
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995965 - Disclosure - Restatement of Previously Issued Consolidated Financial Statements - Summary of Impact of Correction of Misstatements - Corrected Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Details)
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Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale, Total
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale
Proceeds from maturities of available-for-sale short-term investments
Statement [Line Items]
Statement [Line Items]
New aggregate share limit
Share Based Compensation Arrangement By Share Based Payment Award Total Number Of Shares Authorized
Share based compensation arrangement by share based payment award total number of shares authorized.
Entity Addresses, Address Type [Axis]
Plan Name [Domain]
Plan Name
Pre-funded Warrants [Member]
Pre-funded Warrants [Member]
Pre-funded warrants.
Series X1 Non-voting Convertible Preferred Stock [Member]
Series X1 non-voting convertible preferred stock.
Series X1 Non Voting Convertible Preferred Stock [Member]
Series X1 Preferred Stock [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Fair Value, Recurring and Nonrecurring [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Anelixis Therapeutics, LLC and Otic Pharma, Ltd [Member]
Anelixis Therapeutics, LLC and Otic Pharma, Ltd [Member]
Anelixis Therapeutics, LLC and Otic Pharma, Ltd.
Shares, Outstanding
Ending Balance, Shares
Beginning Balance, Shares
Fair Value Hierarchy and NAV [Axis]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Accounts payable, accrued expenses and other liabilities
Accounts payable, accrued expenses and other liabilities
Accounts payable, accrued expenses and other liabilities.
Error Corrections and Prior Period Adjustments Restatement [Line Items]
2024 (remainder of)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Summary of Warrant Liabilities Measured at Fair Value on a Recurring Basis
Deferred tax liabilities
Deferred Income Tax Liabilities, Net
Deferred Income Tax Liabilities, Net, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Document Information [Table]
Description of business.
Description Of Business [Table]
Description Of Business [Table]
Equity [Text Block]
Stockholders' Equity
Description of business.
Description Of Business [Line Items]
Description Of Business [Line Items]
Title and Position [Axis]
Title of Individual
Class of Warrant or Right [Axis]
Sale of Stock [Domain]
Sale of Stock
Cash and Cash Equivalents [Domain]
2014 Employee Stock Purchase Plan [Member]
Two thousand fourteen employee stock purchase plan.
Two Thousand Fourteen Employee Stock Purchase Plan [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Line Items]
Warrants [Member]
Warrant liabilities [Member]
Warrant [Member]
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Securities Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Securities purchase agreement .
Common Stock, Shares, Issued
Common stock, shares issued
Common Stock, Shares, Issued, Total
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, Minimum
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Business Description and Basis of Presentation [Text Block]
Description of Business
Preferred Stock
Preferred Stock [Member]
Issuance of common stock in connection with conversion of X non-voting convertible preferred stock, Shares
Issuance Of Common Stock In Connection With Conversion Of X Non-voting Convertible Preferred Stock Shares
Issuance of common stock in connection with conversion of x non-voting convertible preferred stock shares.
Income Statement [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Prepaid clinical expense.
Prepaid Clinical Expense
Prepaid clinical
Revision of Prior Period [Axis]
Class of Warrant or Right [Table]
Class Of Warrant Or Right [Table]
Biotechnology value fund exchanging stockholders.
Biotechnology Value Fund Exchanging Stockholders [Member]
BVF Exchanging Stockholders [Member]
Increased number of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Class of warrant or right number of warrants or rights cancelled or expired.
Class Of Warrant Or Right Number Of Warrants Or Rights Cancelled Or Expired
Cancelled/Expired
Cover [Abstract]
Subsequent Event [Line Items]
Basic net income (loss) per common share
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Underwriting agreement [Member]
Underwriting Agreement[Member]
Underwriting agreement.
Prior Period Adjustment [Abstract]
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Operating Expenses [Abstract]
Operating expenses
Investments, Debt and Equity Securities [Abstract]
Total stock-based compensation
Share-Based Payment Arrangement, Expense
Stock-based compensation
Conversion Agreement [Member]
Conversion agreement.
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Warrants beneficial ownership limitation percentage
Warrants Beneficial Ownership Limitation Percentage
Warrants beneficial ownership limitation percentage.
Plan Name [Axis]
Plan Name
Regulatory milestone payments obligation.
Regulatory Milestone Payments Obligation
Development and regulatory milestone payments
Cash cash equivalents and restricted cash maturity period.
Cash Cash Equivalents And Restricted Cash Maturity Period
Cash, cash equivalents and restricted cash, maturity period
Assets, Current [Abstract]
Current assets:
Common stock, number of shares reserved for issuance
Common Stock, Capital Shares Reserved for Future Issuance
Liquidity and financial condition.
Liquidity And Financial Condition Policy [Text Block]
Liquidity and Financial Condition
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Prepaid Expenses and Other Current Assets
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Net cash used in Operating Activities
Net cash used in Operating Activities
Stock Issued
Common stock issued in lieu of making a cash payment
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Lessee, Operating Lease, Term of Contract
Operating lease, term of contract
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage
Class of warrant subject to specified beneficial ownership limitations percentage.
Cash flows used in operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Fair Value, Recurring [Member]
Fair Value, Recurring [Member]
Vesting [Axis]
Common stock par value
Common Stock, Par or Stated Value Per Share
Common stock, par value
Stock Options Outstanding [Member]
Issuance Of Common Stock In Connection With Exercise Of Pre-funded Warrants, Value
Issuance of common stock in connection with exercise of pre-funded warrants, Value
Issuance of common stock in connection with exercise of pre-funded warrants, value
Series X Non-Voting Convertible Preferred Stock [Member]
Series X non-voting convertible preferred stock.
Series X Non Voting Convertible Preferred Stock [Member]
Statement of Cash Flows [Abstract]
Counterparty Name [Axis]
Counterparty Name
Schedule of warrant activity.
Schedule Of Warrant Activity Table [Text Block]
Schedule of Warrant Activity
At the market offering program.
At Market Offering Program [Member]
ATM Program [Member]
Office of chief scientist of Israeli ministry of economy and industry.
Office Of Chief Scientist Of Israeli Ministry Of Economy And Industry [Member]
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]
Antidilutive Securities, Name [Domain]
Common stock warrants to purchase common stock shares
Common stock warrants exercisable
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Entity [Domain]
Entity
Area of office space.
Area Of Office Space
Area of office space
Net income (losses) excluding gain of change in fair value of warrant
Net Income (Losses) Excluding Gain Of Change In Fair Value Of Warrant
Net income (losses) excluding gain of change in fair value of warrant.
Equity Components [Axis]
Additional Paid-In Capital [Member]
Biotechnology Value Fund LP, Biotechnology Value Fund II LP, Biotechnology Value Trading Fund OS LP, MSI BVF SPV LLC and Cormorant Global Healthcare Master Fund LP.
Biotechnology Value Fund L P Biotechnology Value Fund I I L P Biotechnology Value Trading Fund O S L P M S I B V F S P V L L C And Cormorant Global Healthcare Master Fund L P [Member]
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member]
Entity Address, Address Line One
Entity Address, Address Line One
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Common Share Equivalents Included from Computation of Net Loss Per Share
Subsequent Event Type [Axis]
Common stock options [Member]
Equity Option [Member]
Summary of Common Share Equivalents were excluded because the Inclusion is Anti-dilutive
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Armistice Capital Master Fund Ltd [Member]
Armistice Capital Master Fund Ltd [Member]
Armistice Capital Master Fund Ltd.
Securities purchase agreement two thousand twenty four.
Securities Purchase Agreement 2024 [Member]
2024 Securities Purchase Agreement
Amendment Flag
Amendment Flag
Warrants Exchanged for Series X1 Preferred Stock.
Warrants Exchanged For Series X1 Preferred Stock [Member]
Warrants Exchanged for Series X1 Preferred Stock [Member]
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Non-current operating lease liabilities
Operating Lease, Liability, Noncurrent
Operating Lease, Liability, Noncurrent, Total
Text Block [Abstract]
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Offering price common stock
Stock price per share
Sale of Stock, Price Per Share
Net income (loss)
Net income (loss)
Net loss and comprehensive loss
Research and Development [Member]
Research and Development Expense [Member]
Equity Component [Domain]
Equity Component
Statistical Measurement [Domain]
Statistical Measurement
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Fee due for milestones achieved.
Fee Due For Milestones Achieved
Fee due for milestones achieved
Securities Purchase Agreement Initial Closing [Member]
Securities Purchase Agreement Initial Closing [Member]
Securities purchase agreement initial closing.
Other income, net
Other income, net
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Operating cash flows from operating leases
Operating Lease, Payments
U.S. Government Agency Securities [Member]
US Government Corporations and Agencies Securities [Member]
All Other Warrants [Member]
All Other Warrants [Member]
All other warrants.
Class of warrant or right number of warrants or rights issued.
Class Of Warrant Or Right Number Of Warrants Or Rights Issued
Issued
Payables and Accruals [Abstract]
Annual license maintenance fee.
Annual License Maintenance Fee
Annual License Maintenance Fee
Net proceeds after deducting offering costs
Proceeds from issuances of common stock and pre-funded warrants, net
Proceeds from Issuance of Common Stock And Pre Funded Warrants Net
Proceeds from issuance of common stock and pre funded warrants net.
Short-term investments
Short-Term Investments
Short-Term Investments, Total
Stock options issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Operating Lease, Expense
Rental expense
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Class of Stock [Domain]
Class of Stock
Other comprehensive income
Other Comprehensive Income (Loss), Net of Tax
Other Comprehensive Income (Loss), Net of Tax, Total
Expected life assumption using simplified method, description
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term, Simplified Method
Comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Purchase of available-for-sale short-term investments
Payments to Acquire Debt Securities, Available-for-Sale
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Private placement two thousand twenty four.
Private Placement 2024 [Member]
2024 Private Placement
Antidilutive Securities [Axis]
Accredited Investor [Member]
Accredited Investor [Member]
Accredited Investor.
Entity Interactive Data Current
Entity Interactive Data Current
Class of warrant or right number of warrants or rights assumed and replaced.
Class Of Warrant Or Right Number Of Warrants Or Rights Assumed And Replaced
Assumed and replaced
Lease Expiration Date
Lease expiration date
Accounting Standards Update [Domain]
Document Quarterly Report
Document Quarterly Report
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Cash and cash equivalents at end of period
Cash and cash equivalents at beginning of period
Cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Total
Statistical Measurement [Axis]
Statistical Measurement
Operating Lease, Cost
Operating lease cost
Stockholders' Equity, Policy [Policy Text Block]
Warrant Liabilities
Total financial assets
Assets, Fair Value Disclosure
Related and Nonrelated Parties [Domain]
Schedule of Future Payments Under Noncancelable Operating Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Gross proceeds
Proceeds from Issuance of Private Placement
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Securities Purchase Agreement Third Closing [Member]
Securities purchase agreement third closing.
Statement of Income Location, Balance [Axis]
Income Statement Location
Cash and Cash Equivalents [Axis]
Assets
Total assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Time-based and Performance-based Vesting Requirements [Member]
Time-based and Performance-based Vesting Requirements [Member]
Time-based and performance-based vesting requirements.
Preferred stock warrants.
Preferred Stock Warrants [Member]
Preferred Stock Warrants [Member]
Aggregate net sales achievement.
Aggregate Net Sales Achievement
Reaching of aggregate net sales
Recently Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Revision of Prior Period, Adjustment [Member]
Restatement Impact [Member]
Accumulated Other Comprehensive Income [Member]
AOCI Attributable to Parent [Member]
Equity [Abstract]
Common stock exchanged for X and X1 non-voting convertible preferred stock
Common Stock Exchanged For X And X One Non-voting Convertible Preferred Stock
Common stock exchanged for X and X1 non-voting convertible preferred stock.
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Schedule of Stock-Based Compensation Expense Recognized
Share Price
Revision of Prior Period [Domain]
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds includes reversal
Change In Fair Value Of Warrant Liabilities And Fair Value Of Financial Instruments Issued In Excess Of Proceeds Includes Reversal
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds includes reversal.
Private Placement [Member]
Private Placement Warrants [Member]
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Prepaid Expense and Other Assets, Current [Abstract]
Operating leases
Operating Lease, Weighted Average Discount Rate, Percent
Schedule of accrued expenses and other liabilities.
Schedule Of Accrued Expenses And Other Liabilities Table [Text Block]
Schedule of Accrued Expenses and Other Liabilities
Fair Value Disclosures [Abstract]
Unrealized gain on available-for-sale securities
Unrealized Gain on Available-for-Sale Securities
Unrealized gain on available-for-sale securities.
Accretion on investment discounts
Accretion on investment discounts
Accretion on Investment Discounts
Accretion on Investment Discounts
Public float minimum balance to be maintained
Public Float Minimum Balance To Be Maintained
Public float minimum balance to be maintained
Lessee operating lease remaining term of contract.
Lessee Operating Lease Remaining Term Of Contract
Remaining term of office lease
Accounting Standards Update 2023-09 [Member]
Accounting Standards Update 2023-09 [Member]
Liabilities, Current [Abstract]
Current liabilities:
Securities purchase agreement second closing.
Securities Purchase Agreement Second Closing [Member]
Securities Purchase Agreement Second Closing [Member]
Document Type
Document Type
Leerink Partners LLC [Member]
Leerink partners LLC.
Accounting Standards Update [Axis]
U.S. Government Securities [Member]
US Government Agencies Debt Securities [Member]
Workers' Compensation Liability, Current
Accrued compensation and related expenses
Title of 12(b) Security
Title of 12(b) Security
Series X One Preferred Stock.
Series X One Preferred Stock [Member]
Series X1 Preferred Stock [Member]
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Lease, Cost [Table Text Block]
Components of Lease Expense
Statement of Stockholders' Equity [Abstract]
Balance as of September 30, 2024
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Balance as of December 31, 2023
Document Fiscal Period Focus
Document Fiscal Period Focus
Research and Development Expense
Research and development
Research and Development Expense, Total
Irvine, California [Member]
CALIFORNIA
Equity distribution agreement.
Equity Distribution Agreement [Member]
Equity Distribution Agreement [Member]
Stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Business Acquisition, Effective Date of Acquisition
Date of acquisition
MASSACHUSETTS
Burlington, Massachusetts [Member]
Address Type [Domain]
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Subsequent Event Type [Domain]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine Fair Value of Stock Options Granted
Error Correction [Table]
Performance-based Vesting Requirements [Member]
Performance-based Vesting Requirements [Member]
Performance-based vesting requirements.
Warrant exercise price
Warrant exercise price per share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Financial Instruments [Domain]
Former Address [Member]
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Sale of Stock [Axis]
Sale of Stock
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Category of Item Purchased [Axis]
Category of Item Purchased
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Statement of Comprehensive Income [Abstract]
Earnings Per Share, Diluted, by Common Class, Including Two-Class Method [Table]
Other Commitments [Table]
Other Commitments [Table]
Anelixis Therapeutics, Incorporation.
Anelixis Therapeutics Incorporation [Member]
Anelixis [Member]
Issuance of Common Stock in Connection with Private Investment in Public Equity Transaction, Net of Issuance Costs, Shares
Issuance of common stock in connection with private investment in public equity transaction, net of issuance costs, shares.
Issuance of common stock and pre-funded warrants in connection with Securities Purchase Agreement, net of issuance costs, Shares
Accounting Standards Update 2023-07 [Member]
Accounting Standards Update 2023-07 [Member]
Debt Securities, Available-for-Sale [Table]
Other Accrued Liabilities, Current
Accrued other
Entity Address, Address Line Two
Entity Address, Address Line Two
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS’ EQUITY
Document Period End Date
Document Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Cash paid for amounts included in the measurement of lease liabilities:
Cash paid for amounts included in measurement of lease liabilities.
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Total
Antidilutive securities excluded from computation of diluted earnings per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Noncash activities:
Noncash Activities [Abstract]
Noncash activities.
Trading Symbol
Trading Symbol
Equity, Attributable to Parent
Ending Balance
Beginning Balance
Total stockholders’ equity
Total stockholders' equity
Guarantor Obligations, Current Carrying Value
Indemnification obligations amount
Earnings Per Share, Diluted, Convertible Security, Method [Extensible Enumeration]
Unrealized gain on available-for-sale securities, net
Unrealized gain (loss) on available-for-sale securities, net
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment and Tax
Warrant to purchase common stock
Class of Warrant or Right, Outstanding
Ending Balance
Beginning Balance
Warrants available for exercise
Conversion of Stock, Shares Issued
Conversion of stock, shares issued
In-Process Research and Development
In Process Research and Development, Policy [Policy Text Block]
Goodwill
Goodwill
Goodwill, Total
Goodwill, Beginning Balance
Goodwill, Ending Balance
Risks and Uncertainties
Risks and Uncertainties [Policy Text Block]
Risks and uncertainties.
Change in accounting principle, accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Geographical [Axis]
Geographical
Unrealized Losses
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Guggenheim Securities LLC [Member]
Guggenheim Securities LLC.
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Issuance of Common Stock in Connection with Private Investment in Public Equity Transaction, Net of Issuance Costs, Value
Issuance of common stock in connection with private investment in public equity transaction, net of issuance costs, value.
Issuance of common stock and pre-funded warrants in connection with Securities Purchase Agreement, net of issuance costs, Value
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Class of Stock [Line Items]
Class Of Stock [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility , Minimum
Common and Preferred Warrants Outstanding [Member]
Common And Preferred Warrants Outstanding [Member]
Common and preferred warrants outstanding.
Weighted-average remaining lease term.
Weighted-Average Remaining Lease Term [Abstract]
Weighted-average remaining lease term
Security Exchange Name
Security Exchange Name
Counterparty Name [Domain]
Counterparty Name
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree
Operating Expenses
Total operating expenses
Accrued severance current.
Accrued Severance Current
Accrued severance
Class of Stock [Axis]
Class of Stock
Legal Entity [Axis]
Legal Entity
2020 Long Term Incentive Plan [Member]
Two thousand twenty long term incentive plan.
Two Thousand Twenty Long Term Incentive Plan [Member]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Lessee, Operating Lease, Liability, to be Paid, Year Three
2027
Conversion of Stock, Shares Converted
Conversion of stock, shares converted
Error Correction [Text Block]
Restatement of Previously Issued Consolidated Financial Statements
Subsequent Event [Member]
Subsequent event
Maximum [Member]
Maximum [Member]
Total liabilities and stockholders' equity
Liabilities and Equity
Number of pre-funded warrants exercised for common stock
Number of Pre-funded Warrants Exercised for Common Stock
Number of pre-funded warrants exercised for common stock.
Operating Lease, Right-of-Use Asset
Operating lease asset, net
ROU assets and lease liabilities
Supplemental Cash Flow Information [Abstract]
Supplemental Cash Flows Information
Basic net income (loss) per common share
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Liabilities
Total liabilities
Total liabilities
Fair Value Hierarchy and NAV [Domain]
Assets, Current
Total current assets
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Stock Issued During Period, Shares, New Issues
Common stock number of shares issued
Increase decrease in operating lease asset and liability due to new lease.
Increase Decrease in Operating Lease Asset and Liability Due To New Lease
Increase in operating lease asset and liability due to new lease
Vesting period of stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Entity Filer Category
Entity Filer Category
Net proceeds after deducting offering costs
Proceeds from Issuance of Private Placement, Net of Offering Costs
Proceeds from issuance of private placement, net of offering costs.
Working capital.
Working Capital
Working capital
Net income (loss) attributable to common shares - basic
Net income (loss) attributable to common shares - diluted
Net Income (Loss) Available to Common Stockholders, Diluted
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Abstract]
Common stock warrants.
Common Stock Warrants [Member]
Common Stock Warrants [Member]
Current Fiscal Year End Date
Current Fiscal Year End Date
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less imputed interest
Discount rate.
Discount Rate [Abstract]
Discount rate
Related and Nonrelated Parties [Axis]
Net proceeds after deducting offering costs
Proceeds From Issuance Of Net Of Offering Costs
Proceeds from issuance of net of offering costs.
Entity Registrant Name
Entity Registrant Name
Allocated undistributed earnings allocated to participating securities
Undistributed Earnings (Loss) Allocated to Participating Securities, Diluted
Undistributed Earnings (Loss) Allocated to Participating Securities, Diluted, Total
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Net Income/Loss Per Share
Earnings Per Share [Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Money Market Funds [Member]
Money Market Funds [Member]
Weighted-average number of shares outstanding, Basic
Basic weighted-average common shares outstanding
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Vesting [Domain]
Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility , Maximum
Common Stock, Shares Authorized
Common stock, shares authorized
Proceeds from Issuance of Common Stock
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock
Issuance of common stock in connection with conversion of X1 non-voting convertible preferred stock, Value
Issuance Of Common Stock In Connection With Conversion Of X1 Non-voting Convertible Preferred Stock Value
Issuance of common stock in connection with conversion of X1 non-voting convertible preferred stock value.
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Number of days after registration settlement
Number of Days After Registration Settlement
Number of days after registration settlement.
Financial Instrument [Axis]
Long-Term Purchase Commitment, Category of Item Purchased [Domain]
Long-term Purchase Commitment, Category of Item Purchased
General and Administrative [Member]
General and Administrative Expense [Member]
Share-Based Payment Arrangement [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Time-based Vesting Requirements [Member]
Time-based Vesting Requirements [Member]
Time-based vesting requirements.
Potentially dilutive common shares:
Dilutive Securities, Effect on Basic Earnings Per Share [Abstract]
Common warrants issued
Proceeds from issuance of pre-funded warrants
Proceeds from Issuance of Warrants
Fair Value
Debt Securities, Available-for-Sale
Debt Securities, Available-for-Sale, Total
Accounting Policies [Abstract]
Undistributed earnings allocated to participating securities
Undistributed earnings allocated to participating securities
Undistributed Earnings (Loss) Allocated to Participating Securities, Basic
Undistributed Earnings (Loss) Allocated to Participating Securities, Basic, Total
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash investing and financing activities
Statement [Table]
Statement [Table]
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Subsequent Event [Table]
Accrued Liabilities and Other Liabilities [Abstract]
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Securities Act File Number
Entity File Number
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net change in cash and cash equivalents
Earnings Per Share [Abstract]
Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage
Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage
Class of warrant subject to specified beneficial ownership limitations permitted percentage.
Statement of Financial Position [Abstract]
Operating Income (Loss)
Loss from operations
Issuance Of Common Stock In Connection With Exercise Of Pre-funded Warrants Shares
Issuance of common stock in connection with exercise of pre-funded warrants, Shares
Issuance of common stock in connection with exercise of pre-funded warrants, shares.
Shares Issued, Price Per Share
Shares price per share
Entity Shell Company
Entity Shell Company
Accrued Professional Fees, Current
Accrued professional services
Entity Tax Identification Number
Entity Tax Identification Number
Assets [Abstract]
ASSETS
Schedule of Error Corrections and Prior Period Adjustments [Table Text Block]
Summary of Impact of Correction of Misstatements
Settlement of warrant liability
Settlement of Warrant Liability
Settlement of warrant liability.
Class of Warrant or Right [Domain]
Entity Current Reporting Status
Entity Current Reporting Status
Net income (loss) attributable to common shares - basic
Net income (loss) attirbutable to common shares - basic
Net Income (Loss) Available to Common Stockholders, Basic
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Aggregate Fair Values of Warrant Liability
Subsequent Events [Abstract]
Previously Reported [Member]
As Previously Reported [Member]
Geographical [Domain]
Geographical
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash and cash equivalents and short-term investments
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
In-process research and development.
In Process Research And Development
In-process research and development
Preferred Stock, Value, Issued
Preferred stock, value
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Other information related to leases.
Other Information Related To Leases Table [Text Block]
Schedule of Other Information Related to Leases
Business Acquisition [Axis]
Business Acquisition
City Area Code
City Area Code
Grodd proceeds
Proceeds From Issuance Offering
Proceeds from issuance offering
Debt outstanding
Debt, Long-Term and Short-Term, Combined Amount
Debt, Long-Term and Short-Term, Combined Amount, Total
Liabilities, Current
Total current liabilities
Jefferies Limited Liability Company.
Jefferies Limited Liability Company [Member]
Jefferies LLC [Member]
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds.
Change in Fair Value of Warrant Liabilities and Fair Value of Financial Instruments Issued in Excess of Proceeds
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds
Accrued Liabilities and Other Liabilities
Accrued expenses and other liabilities
Total accrued expenses and other liabilities
Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments [Text Block]
Otic Pharma, Inc.
Otic Pharma Inc [Member]
Otic Pharma, Inc. [Member]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Conversion of preferred stock, conversion blocker, percent
Conversion of Preferred Stock, Conversion Blocker, Percent
Conversion of preferred stock, conversion blocker, percent.
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Remaining milestone payments for first licensed product.
Remaining Milestone Payments For First Licensed Product
Remaining milestone payments for first licensed product
Commitments and Contingencies Disclosure [Abstract]
Preferred stock conversion to common stock [Member]
Convertible Preferred Stock [Member]
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
2014 Stock Incentive Plan [Member]
Two thousand fourteen stock incentive plan.
Two Thousand Fourteen Stock Incentive Plan [Member]
Five hundred million aggregate net sales.
Five Hundred Million Aggregate Net Sales [Member]
Achievement of 500 Million Aggregate Sales [Member]
Less current portion of operating lease liabilities
Current operating lease liabilities
Operating Lease, Liability, Current, Total
Operating Lease, Liability, Current
Document Information [Line Items]
Convertible Preferred Stock, Shares Issued upon Conversion
Shares of common stock issued upon conversion of each share of preferred stock
Retained Earnings [Member]
Accumulated Deficit [Member]
Board of Directors [Member]
Board of Directors Chairman [Member]
Class of warrant or right number of warrants exercised.
Class Of Warrant Or Right Number Of Warrants Or Rights Exercised
Exercised
Document Transition Report
Document Transition Report
Prepaid expenses and other current assets.
Prepaid Expenses And Other Current Assets [Text Block]
Prepaid Expenses and Other Current Assets
Series X convertible preferred stock.
Series X Convertible Preferred Stock [Member]
Series X Non-voting Convertible Preferred Stock [Member]
Lessee, Operating Lease, Liability, to be Paid, Year Two
2026
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds, net of tax
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds, net of tax
Change In Fair Value Of Warrant Liabilities And Fair Value Of Financial Instruments Issued In Excess Of Proceeds, Net Of Tax
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds, net of tax.
Antidilutive Security, Excluded EPS Calculation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
BVF Exchanging Stockholders [Member]
Biotechnology Value Fund LP, Biotechnology Value Fund II LP, Biotechnology Value Trading Fund OS LP, MSI BVF SPV LLC.
Biotechnology Value Fund L P Biotechnology Value Fund I I L P Biotechnology Value Trading Fund O S L P M S I B V F S P V L L C [Member]
Minimum [Member]
Minimum [Member]
Unrealized gain on available-for-sale short term investments
Unrealized Gain (Loss) on Investments
Common Stock [Member]
Common Stock [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Additional Paid-in Capital [Member]
Additional Paid-In Capital [Member]
Settlement of warrant liability into common stock due to exercise
Settlement Of Warrant Liability Into Common Stock Due To Exercise
Settlement of warrant liability into common stock due to exercise.
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Equity distribution agreement maximum value of common shares issuable.
Equity Distribution Agreement Maximum Value Of Common Shares Issuable
Equity distribution agreement maximum value of common shares issuable
Statement of Income Location, Balance [Domain]
Income Statement Location
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
Other Assets, Noncurrent
Other assets
Other Assets, Noncurrent, Total
Other Prepaid Expense, Current
Prepaid other
Other Assets, Current
Other current assets
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
U.S. Government Agency Securities [Member]
US Government Agencies Short-Term Debt Securities [Member]
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Title and Position [Domain]
Title of Individual
Table Text Block Supplement [Abstract]
Warrants and Rights Outstanding
Warrant liabilities
Balance as of December 31, 2023
Balance as of June 30, 2024
Warrant liabilities
Royalty Guarantees, Commitments, Amount
Amount of one-time milestone payment
Common stock, $0.001 par value, 200,000,000 shares authorized at September 30, 2024 and December 31, 2023; 41,183,102 and 24,213,130 shares issued and outstanding at September 30, 2024 and December 31, 2023, respectively
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock
Issuance of common stock in connection with conversion of X1 non-voting convertible preferred stock, Shares
Issuance Of Common Stock In Connection With Conversion Of X1 Non-voting Convertible Preferred Stock Shares
Issuance of common stock in connection with conversion of X non-voting convertible preferred stock shares.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Prepaid Insurance
Prepaid insurance
Potentially dilutive common shares, Common stock warrants
Dilutive Securities, Effect on Basic Earnings Per Share, Dilutive Convertible Securities
Total cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Cash and Cash Equivalent [Table]
Financial Instruments Measured At Fair Value On A Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Amortization of operating lease asset.
Amortization Of Operating Lease Asset
Amortization of operating lease asset
Proceeds from issuance of common stock with exercise of pre-funded warrants.
Proceeds From Issuance Of Common Stock With Exercise Of Pre-funded Warrants
Proceeds from issuance of common stock with exercise of pre-funded warrants
Operating Lease, Liability
Present value of lease liabilities
Cormorant Global Healthcare Master Fund LP [Member]
Cormorant Global Healthcare Master Fund LP [Member]
Cormorant global healthcare master fund lp.
Summary of Short-term Investments Classified as Available-for-sale Securities
Debt Securities, Available-for-Sale [Table Text Block]
Going Concern and Management's Plans
Substantial Doubt about Going Concern [Text Block]
Measurement Frequency [Axis]
Commitments and contingencies (Note 7)
Commitments and Contingencies
Weighted-average number of common shares outstanding, diluted
Weighted-average number of shares outstanding, Diluted
Weighted-average common shares outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Lessee, Operating Lease, Liability, to be Paid
Total minimum lease payments
Subsidiary or Equity Method Investee, Cumulative Percentage Ownership after All Transactions
Ownership interest percentage
Entity Small Business
Entity Small Business
One billion aggregate net sales.
One Billion Aggregate Net Sales [Member]
Achievement of 1 Billion Aggregate Sales [Member]
Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]
U.S. Treasuries [Member]
US Treasury Securities [Member]
Total short-term investments
Total short-term investments
Investments, Fair Value Disclosure
ALS therapy development foundation, Inc. license agreement.
A L S Therapy Development Foundation Inc License Agreement [Member]
ALS Therapy Development Foundation, Inc. License Agreement [Member]
Accrued clinical current.
Accrued Clinical Current
Accrued clinical
Securities Purchase Agreement Second and Third Closing [Member]
Securities Purchase Agreement Second And Third Closing [Member]
Securities purchase agreement second and third closing.
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Accrued Expenses and Other Liabilities
Contingent liabilities
Contingent liability.
Contingent Liability
Measurement Frequency [Domain]
Number of milestones achieved.
Number Of Milestones Achieved
Number of Milestones Achieved
Fair Value, Inputs, Level 3 [Member]
Fair Value Inputs, Level 3 [Member]
Operating leases
Operating Lease, Weighted Average Remaining Lease Term
Subsequent Events [Text Block]
Subsequent Events
Share-Based Payment Arrangement [Member]
Stock Options Outstanding and Other Equity Awards [Member]
Gain (Loss) on Termination of Lease
Gain on lease termination
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Liabilities, Fair Value Disclosure, Total
Liabilities, Fair Value Disclosure
Liabilities measured at fair value